Análisis a la información de costos y gastos generada en la sede Almacentro del Hospital Mental para determinar la rentabilidad obtenida

Mental Hospital of Antioquia, seeking to be more competitive in the marketplace, extended its coverage in the alternative site located in the Mall Almacentro, which provides outpatient services for Medical Specialist Psychiatrist, Medical subspecialists, Child Psychiatry, Outpatient by Medical Specialist Neurologist and outpatient drug market through the sale of pharmacy. Each business unit which makes up seat is making a number of costs that independently analyzed show a disproportionate distribution in relation to the generation of income. Currently the costs for outpatient services are not covered by income, only to consolidate the information casts reasonable results, to analyze the return produced. For the development of this paper we analyze the different components of the costs associated with the provision of outpatient services and sale of pharmaceutical products to determine the variables that affect the return in each business unit individually and consolidated headquarters Almacentro. The analysis was performed using spreadsheets, which were detailed in hospital costs for labor, supplies, overhead, distribution costs, among others, the collection of these data and the application of the linear estimation formula, we set the total variable and fixed costs, elements that allowed us to make the break-even analysis and contribution margin for the consultation service and product sales pharmaceutical required in the recovery of costs incurred and analysis generated in the consolidated return of information from headquarters.El Hospital Mental de Antioquia, buscando ser más competitivo en el mercado, amplió su cobertura, con la sede alterna ubicada en el Centro Comercial Almacentro, donde se presta los servicios de Consulta Externa por Médico Especialista Psiquiatra, Médico Subespecialista, Psiquiatría Infantil, Consulta Externa por Médico Especialista Neurólogo y comercialización de medicamentos ambulatorios a través de la venta de farmacia. Cada unidad de negocio, que conforma esta sede, está incurriendo en una serie de costos que analizados independientemente muestran una distribución desproporcionada, en relación con la generación de los ingresos. Actualmente los costos por servicio de consulta externa, no son cubiertos con los ingresos, solo al consolidar la información arroja resultados razonables, para analizar la rentabilidad producida. Para el desarrollo de este trabajo analizamos los diferentes componentes de los costos asociados con la prestación del servicio de consulta externa y la venta de productos farmacéuticos para determinar las variables que afectan la rentabilidad en cada unidad de negocio de manera individual y el consolidado de la sede Almacentro. El análisis lo realizamos a través de hojas de cálculo, en las cuales se detallaron los costos hospitalarios de mano de obra, suministros, gastos generales, costos distribuidos, entre otros y con la recopilación de estos datos y con la aplicación de la fórmula de estimación lineal, establecimos los costos variables y fijos totales, elementos que nos permitió realizar el análisis de punto de equilibrio y margen de contribución para el servicio de consulta y venta de productos farmacéuticos requeridos en la recuperación de los costos incurridos, así como el análisis de la rentabilidad generada en el consolidado de la información de la sede

Modeling of allergen proteins found in sea food products Modelagem de proteínas alergênicas em frutos do mar

Shellfish are a source of food allergens, and their consumption is the cause of severe allergic reactions in humans. Tropomyosins, a family of muscle proteins, have been identified as the major allergens in shellfish and mollusks species. Nevertheless, few experimentally determined three-dimensional structures are available in the Protein Data Base (PDB). In this study, 3D models of several homologous of tropomyosins present in marine shellfish and mollusk species (Chaf 1, Met e1, Hom a1, Per v1, and Pen a1) were constructed, validated, and their immunoglobulin E binding epitopes were identified using bioinformatics tools. All protein models for these allergens consisted of long alpha-helices. Chaf 1, Met e1, and Hom a1 had six conserved regions with sequence similarities to known epitopes, whereas Per v1 and Pen a1 contained only one. Lipophilic potentials of identified epitopes revealed a high propensity of hydrophobic amino acids in the immunoglobulin E binding site. This information could be useful to design tropomyosin-specific immunotherapy for sea food allergies.<br>Os mariscos são fontes de alérgenos alimentares e seu consumo é a causa de graves reações alérgicas em humanos. Tropomiosinas, uma família de proteínas musculares, foram identificadas como os principais alérgenos em espécies de crustáceos e moluscos. No entanto, poucas estruturas experimentais tridimensionais estão disponíveis no Protein Data Base (PDB). Neste trabalho, modelos 3D de vários homólogos de tropomiosinas presentes em moluscos marinhos e espécies de moluscos (Chaf 1, Met e1, Hom a1, v1 Per e Pen a1) foram construídas, validadas e seus epítopos de ligação de imunoglobulina E (IgE) foram identificados, utilizando ferramentas de bioinformática. Todos os modelos de proteína para esses alérgenos consistiam em longas alfa-hélices. Chaf 1, Met e1, e Hom a1 apresentaram seis regiões conservadas com similaridades de sequência para epítopos conhecidos, enquanto v1 Per e Pen a1 único. Potenciais lipofílicos de epítopos identificados revelaram uma alta propensão de aminoácidos hidrofóbicos em sítio de ligação IgE. Esta informação poderia ser útil para projetar imunoterapia específica para tropomiosina para alergias alimentares

Modeling of allergen proteins found in sea food products

Shellfish are a source of food allergens, and their consumption is the cause of severe allergic reactions in humans. Tropomyosins, a family of muscle proteins, have been identified as the major allergens in shellfish and mollusks species. Nevertheless, few experimentally determined three-dimensional structures are available in the Protein Data Base (PDB). In this study, 3D models of several homologous of tropomyosins present in marine shellfish and mollusk species (Chaf 1, Met e1, Hom a1, Per v1, and Pen a1) were constructed, validated, and their immunoglobulin E binding epitopes were identified using bioinformatics tools. All protein models for these allergens consisted of long alpha-helices. Chaf 1, Met e1, and Hom a1 had six conserved regions with sequence similarities to known epitopes, whereas Per v1 and Pen a1 contained only one. Lipophilic potentials of identified epitopes revealed a high propensity of hydrophobic amino acids in the immunoglobulin E binding site. This information could be useful to design tropomyosin-specific immunotherapy for sea food allergies